Why the study?
Hypertension remains poorly controlled in the Russian population partly due to low patient compliance, which is driven by multiple factors.
Do fixed-dose combinations of antihypertensive drugs improve treatment compliance in patients with hypertension?
Do fixed-dose combinations of antihypertensive drugs improve treatment compliance in patients with hypertension?
Fixed-dose combinations of antihypertensive drugs may improve treatment adherence in patients with hypertension.
Answers are grounded in this paper and cite their sources.
Fixed-dose combinations may aid adherence in Russian hypertension; hypothesis-generating from Level 5 data, RCTs needed.
With a high prevalence in the Russian population and insufficient effectiveness of treatment, hypertension remains a poorly controlled cardiovascular risk factor, including due to the low compliance of patients. Noncompliance is due to a large number of factors, some of which were studied in post-hoc analysis of the Russian observational STIL’ and TRICOLOR studies. It demonstrated that fixed-dose combinations of antihypertensive drugs can make a significant contribution to solving such a complex problem as low compliance.
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Boytsov et al. (2022) studied this question.
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