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This case series identifies a potential association between X-linked thyroxine-binding globulin deficiency and hyperlipoproteinemia, though the mechanism remains unclear.
A kindred was presented in which 4 members in 3 generations showed absent or reduced serum concentrations of thyroxine-binding globulin (TBG). TBG was undetectable by radioimmunoassay in males and decreased in females. The mode of transmission of the trait was consistent with X-chromosome linkage.Hyperlipoproteinemia was also present in 3 members with TBG abnormalities. Hyperlipoproteinemia was combination the type II and the type IV.The mechanisms responsible for hyperlipoproteinemia in TBG abnormality remained obscure.
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Yoshioka et al. (1982) studied this question.
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