Rhodium‐Catalyzed Asymmetric [5+2] Cycloaddition of Alkyne–Vinylcyclopropanes

Easy to scale: A rhodium-catalyzed asymmetric intramolecular [5+2] cycloaddition of alkyne–vinylcyclopropanes has been developed. High enantioselectivities of up to >99.5 % ee have been achieved by the use of a chiral phosphoramidite ligand. The reaction can be easily scaled up and the stereochemical model of the present catalysis has also been proposed.