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The metabolic-associated fatty liver disease (MAFLD) criteria1 is aimed at capturing the heterogeneity of the disease with the goal of improving patient stratification and management. However, as is well-known, the metabolic factors used in the nomenclature are complex and correlated, and their nuanced contribution to the definition needs to be quantified to accurately estimate clinical relevance and stratify the population at risk.2
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Claypool et al. (2022) studied this question.
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