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January 9, 2017Proceedings of the National Academy of SciencesOpen Access

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection

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Why the study?

Does exogenous IFN treatment restrict human rotavirus replication in human intestinal enteroids?

Population

Nontransformed human intestinal enteroid cultures from multiple individuals infected with human rotavirus

Comparison

Exogenous interferon treatment vs Endogenous response / untreated

Design

Preclinical

Authors

KSKapil SaxenaLSLukas M. SimonXZXi-Lei Zeng

Discussion

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Overview

Human enteroid data indicate type I IFN outperforms type III in restricting rotavirus; leaves open whether extraepithelial sources drive intestinal antiviral defense.

Structured PICO

Does exogenous IFN treatment restrict human rotavirus replication in human intestinal enteroids?

P
Population
Nontransformed human intestinal enteroid cultures from multiple individuals infected with human rotavirus (HRV)
I
Intervention
Exogenous interferon (IFN) treatment (type I and type III)
C
Comparator
Endogenous response / untreated
O
Outcome
Host epithelial response and restriction of HRV replicationsurrogate

Type I interferon is more potent than type III interferon in restricting human rotavirus replication in human intestinal enteroids, suggesting extraepithelial sources of type I IFN are critical for limiting enteric virus replication.

Cite This Study

Saxena et al. (2017) studied this question.

synapsesocial.com/papers/6a742412e50bdaa0a433f841https://doi.org/10.1073/pnas.1615422114
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