Injection of collagenase from Clostridium Histolyticum (CCH) in Dupuytren’s disease weakens diseased cords sufficiently to enable subsequent rupture and finger extension. The effects of CCH, however, are limited to the injection area, meaning that palpable traces of cord remain proximally and distally to the injection site.
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Rafael Sanjuán-Cerveró (2025) studied this question.
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