A continuous‐flow protocol for the gold‐catalyzed cycloisomerization of sterically hindered Ugi‐adducts to spiroindolines in a packed‐bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the catalyst deactivation process was conducted, whereas no metal leaching from the catalyst was detected. magnified image
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Schrӧder et al. (2015) studied this question.
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