In prosecution of earlier studies from this laboratory, a detailed investigation on the potentialities of differential enthalpic analysis (DEA) in the evaluation of enthalpies of thermal denaturation as welt as of activation energies for the denaturation processes of three different proteins in concentrated aqueous solutions has been carried out. Our results suggest that DEA may indeed be an useful tool for the evaluation of such thermal and kinetic parameters despite some difficulties encountered in quantitation mainly because of the high biopolymer concentrations necessary with the DEA apparatuses available.
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Crescenzi et al. (1971) studied this question.
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