Why the study?
What is the frequency of TRPM4 gene mutations in patients with inherited cardiac arrhythmic syndromes?
Population
160 unrelated patients with various types of inherited cardiac arrhythmic syndromes
Comparison
TRPM4 gene mutation screening vs Control individuals
Design
Cross-sectional
Authors
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TRPM4 screening may be prioritized in conduction disease; supports gene-disease links but leaves broader arrhythmic roles open for validation.
What is the frequency of TRPM4 gene mutations in patients with inherited cardiac arrhythmic syndromes?
TRPM4 gene mutations play a major role in cardiac conduction disease (AV block, RBBB) but not in other related syndromes like Brugada or long-QT syndrome.
Stallmeyer et al. (2011) studied this question.
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