Key result
Heart failure is linked to an ~89% higher risk of incident PVCs.
Why the study?
Population-level predictors of clinically diagnosed premature ventricular complexes in acute care settings remain unclear despite their clinical significance and associations with adverse outcomes.
Cohort (n=20,234,245)
Hazard Ratio: 1.89
p-value: p=<0.001
In a large population-based cohort, clinically diagnosed PVCs in acute care settings were strongly associated with older age, male sex, substance use (particularly amphetamines), and cardiovascular comorbidities such as heart failure.
Jean Jacques Noubiap, MD, PhD, Gabrielle C Montenegro, BA, Catherine Lee, PhD, Janet J Tang, PhD, MPH, Thomas A Dewland, MD, Edward P Gerstenfeld, MD, MS,
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Noubiap et al. (2026) conducted a cohort in Premature ventricular complexes (n=20,234,245). Heart failure vs. No heart failure was evaluated on Incident clinically diagnosed PVC (HR 1.89, p=<0.001). In a cohort of over 20 million adults, incident clinically diagnosed premature ventricular complexes were strongly associated with heart failure (HR 1.89) and amphetamine use (HR 1.52).
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