Key result
A 5-period crossover design with two placebo periods for thorough QT studies correctly calculates variance and maintains overall blinding, allowing for a reduced sample size compared to a 4-period design.
Design
Editorial
The authors mathematically confirm that a 5-period double-placebo crossover design for thorough QT studies is more efficient than a standard 4-period design, allowing for a reduced sample size while maintaining assay sensitivity.
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Ring et al. (2026) reported a letter. A 5-period crossover design with two placebo periods for thorough QT studies correctly calculates variance and maintains overall blinding, allowing for a reduced sample size compared to a 4-period design.
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