Molecular basis of Arabidopsis ABCC2 in plant detoxification

The detoxification of phytotoxic compounds is a prerequisite for plant survival. ATP-binding cassette family C (ABCC) transporters play a pivotal role in the export of toxic compounds into vacuoles, a critical step in detoxification 1 . Arabidopsis thaliana ABCC2 ( At ABCC2) is responsible for the efflux of glutathione conjugates of pesticides, such as atrazine and metolachlor, into the vacuoles 2 , 3 , 4 , 5 . Additionally, At ABCC2 can export arsenic-phytochelatin conjugates into vacuoles, resulting in increased arsenic tolerance 6 , 7 . Despite its critical role in plant detoxification, the biochemical and structural mechanisms underlying the function of At ABCC2 remain incompletely understood.