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August 6, 2026ChemMedChem

New 1,2,3‐Triazole Hybrids as Anticancer Agents: Design, Synthesis, Characterization, and In Silico Studies

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Authors

ASAlírica I. SuárezKCKatiuska ChávezPMPablo Martínez

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Overview

Randomized trial evaluates cytotoxicity of 1,2,3‐triazole hybrids against cancer cells, suggesting new treatment pathways.

Key Points

  • The aim is to design and evaluate the anticancer activity of 1,2,3‐triazole hybrids against various cancer cell lines.
  • Two series of 1,2,3‐triazole compounds were synthesized and characterized.
  • Cytotoxicity was assessed against tumor and normal cell lines, including lymphocytes and various cancer lines.
  • In silico studies were conducted to analyze the interactions of compounds with protein kinase A.
  • Compounds 18 and 20 showed selective activity against BJ and A549 cell lines, with compound 20 selective for T‐cell leukemias.
  • Compound 14 exhibited high specificity for T‐cell leukemia, while compound 19 was specific for A549.
  • Active compounds were found to induce apoptosis, activating caspase 3; high binding affinity for protein kinase A was demonstrated.

Cite This Study

Suárez et al. (2026) studied this question.

synapsesocial.com/papers/6a7437f4764cddc9499d5cffhttps://doi.org/10.1002/cmdc.70425
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