Pharmacological Evaluation of Dazzle Cool Cream for Anti Inflammatory and Analgesic Activity

Musculoskeletal injuries are most common risk factors for sport persons. Pain and swelling are the most common associated symptoms of such injuries. A use of non-steroidal anti-inflammatory drugs (NSAIDs) has been routine in the management of musculoskeletal inflammation and pain. Although effective at reducing pain and inflammation, NSAIDs may not be appropriate to use frequently or longer time due to their known side effects. Herbal and Ayurvedic products are widely perceived as safe due to their natural origin and long historical clinical use. Hence in the present study, Dazzle Cool Cream -An Ayurvedic proprietary formulation has been selected for evaluation of its anti-inflammatory and analgesic activity. Anti-inflammatory activity was evaluated by Complete freund's adjuvant (CFA) induced acute and chronic phase inflammation. Analgesic activity was evaluated by Hot plate method and Tail flick method. Total study was performed on 10 groups of animal where each group was containing 6 animals. Marketed gel containing Diclofenac diethylamine BP 1.16 % w/w was considered as standard drug for both activities. Paw volume was significantly lowered at 7 th , 14 th and 21 st day in test drug and standard drug group with respect to disease control. Dazzle Cool Cream showed 28.16 % inhibition in paw volume at 21 st day which was comparable to standard marketed gel containing Diclofenac diethylamine BP 1.16 % w/w showing 29.88 % inhibition. Dazzle Cool Cream showed significant effect on inflammatory markers such as ESR, CRP and WBC. It also exhibited significant analgesic activity in both Hot plate and Tail flick nociceptive tests. On the basis of available results, it can be concluded that Dazzle Cool Cream has promising anti-inflammatory and analgesic activity.