Scoping out TIMO: A telescoped intramolecular Michael addition/proton transfer/Horner–Wadsworth–Emmons olefination sequence was developed to provide rapid access to α-alkylidene-γ-butyrolactones (see scheme). The method was applied to prepare a range of tetrahydrobenzofuran-2,5-diones and related systems, and it was utilized in a short synthesis of enantiomerically pure (+)-paeonilactone B.
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Edwards et al. (2008) studied this question.
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