Key result
Isolated guinea-pig ileum assays renin and hypertensin with sensitivity matching the vascular toad preparation.
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Renin and hypertensin may be easily assayed with the isolated guinea-pig ileum, which is as sensitive as the vascular toad preparation. Hypertensin itself is the substance which acts on the smooth muscle of the ileum.
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Picarelli et al. (1954) studied this question. The isolated guinea-pig ileum easily assays renin and hypertensin with sensitivity equal to the vascular toad preparation, mediated by hypertensin acting on smooth muscle.
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