Sequential Changes of the Plasma Protein Pattern in Inoculation Hepatitis

22 plasma proteins were followed in inoculation hepatitis for two months after onset of icterus. Increased plasma ai-antitrypsin combined with normal orosomucoid and decreased haptoglobin level are charcteristic findings. The immunoglobulins show only insignificant changes. Abnormal complement activation seems to be uncommon. Low prealbumin and a-lipoprotein values are regular findings in periods with pronounced enzyme leakage from the liver. The immunologic reactivity of the a-Iipoproteins changes during the course of the disease.