Why the study?
Does the aldosterone synthase (CYP11B2) gene polymorphism increase the risk of severe white matter hyperintensities in older adults?
Does the aldosterone synthase (CYP11B2) gene polymorphism increase the risk of severe white matter hyperintensities in older adults?
The T allele of the aldosterone synthase (CYP11B2) gene is associated with an increased risk of severe cerebral white matter hyperintensities in men, independent of hypertension.
Should not alter clinical management; leaves open a sex-specific genetic link to severe WMH requiring prospective confirmation.
The association between aldosterone synthase (CYP11B2) gene polymorphism and white matter hyperintensities seen on cerebral MRI was studied in a population-based sample of 829 individuals aged 63 to 75 years. The T allele was associated with the risk of severe white matter hyperintensities. Compared with the CC genotype, the adjusted OR for severe white matter hyperintensities was 4.61 (95% CI, 1.46 to 14.55) for the TT genotype and 2.45 (95% CI, 0.81 to 7.46) for the TC genotype in men. This association was independent of hypertension.
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Verpillat et al. (2001) studied this question.
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