Key result
Carriage of the -174C IL-6 promoter variant was not associated with increased coronary artery disease risk in Tunisians compared to GG carriers (OR 1.09; 95% CI 0.80-1.49).
Case-Control (n=824)
BACKGROUND AND OBJECTIVES: A state of low-grade inflammation accompanies the pathogenesis of atherosclerotic events. Interleukin-6 (IL-6) is a pleotropic pro-inflammatory cytokine that modulates the development of acute coronary syndromes (ACSs), partly by destabilizing coronary atherosclerotic plaques. We have examined the contribution of the -174G>C IL-6 promoter variant on the risk of coronary artery disease (CAD) among Tunisians. PATIENTS AND METHODS: Study subjects included 418 CAD patients and 406 age- and sex-matched controls. IL-6 genotyping was done by PCR-restriction fragment length polymorphism. RESULTS: The frequency of the -174C allele (mutant) was lower in Tunisians than in Europeans, and the distribution of -174 G>C genotypes was similar between CAD patients and control subjects. Moreover, compared to GG genotype carriers, -174C allele carriage did not increase the CAD relative risk (odds ratio and 95% confidence interval=1.09 and 0.80-1.49), which remained nonsignificant after adjusting for traditional risk factors for CAD (age, smoking, hypertension, diabetes and obesity). CONCLUSION: The -174G>C IL-6 promoter variant is not associated with an increased risk of CAD among Tunisians.
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Ghazouani et al. (2011) conducted a case-control in Coronary artery disease (n=824). -174G>C IL-6 promoter polymorphism (-174C allele carriage) vs. GG genotype carriers was evaluated on Coronary artery disease (CAD) (OR 1.09, 95% CI 0.80-1.49). Carriage of the -174C IL-6 promoter variant was not associated with increased coronary artery disease risk in Tunisians compared to GG carriers (OR 1.09; 95% CI 0.80-1.49).
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