Key result
In a retrospective review of seven patients with free-floating thrombus of the aorta, initial treatment with systemic anticoagulation led to complete dissolution of the thrombus in three of four patients, with no recurrences during follow-up.
Observational (n=7)
No
Systemic anticoagulation with LMWH is an effective first-line treatment for free-floating thrombus of the aorta, with surgery reserved for persistent thrombus or recurrent embolism.
Anticoagulation may promote resolution in free-floating aortic thrombus; leaves open optimal strategies pending prospective data.
Purpose: Free-floating thrombus (FFT) of the aorta is very rare but has a high risk of distal embolization. While the necessity of treating such a condition is evident, the diagnostic and therapeutic modalities remain controversial. Thus, we reviewed seven cases of FFT of the aorta. Methods: A retrospective study was performed usings even patients diagnosed with FFT of the aorta at the Catholic University of Korea between January 1999 and December 2008. We excluded those patients who had thrombi with concomitant atherosclerotic or aneurysmal aorta. Results: The mean patient age was 59.6±13.6 years old. The male-to-female ratio was 3:4. Embolization to arteries of the extremities occurred in two patients and to visceral arteries in four patients. Of these seven patients, four were initially treated with anticoagulation, and two were initially treated with thrombectomy; one patient refused any kind of treatment. Of the four patients treated with anticoagulation, three experienced complete dissolution of the thrombi while anticoagulation proved ineffective in the remaining patient who subsequently underwent thrombectomy. In all of the three patients who had received thrombectomy, postoperative anticoagulation was employed. There was no recurrence of FFT of the aorta during the follow-up period. Conclusion: Were commend systemic anticoagulation with low molecular weight heparin (LMWH) as the first line of treatment for FFT of the aorta. If the thrombus persists or recurrent embolism occurs during anticoagulation therapy, surgery should be undertaken. (J Korean Surg Soc 2011;80:204-211)
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Kim et al. (2011) conducted an observational in Free-floating thrombus of the aorta (n=7). Systemic anticoagulation (LMWH) or thrombectomy was evaluated on Complete dissolution of thrombus and recurrence of free-floating thrombus. In a retrospective review of seven patients with free-floating thrombus of the aorta, initial treatment with systemic anticoagulation led to complete dissolution of the thrombus in three of four patients, with no recurrences during follow-up.
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