F13A1 Gene Variant (V34L) and Residual Circulating FXIIIA Levels Predict Short- and Long-Term Mortality in Acute Myocardial Infarction after Coronary Angioplasty

Figures

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  Figure 1. (A) Distribution of patients carrying FXIIIA VV34 genotype or L34-allele stratified by FXIIIA quartiles (I-IV) assessed at baseline (d0; left panel) and four days (d4; right panel) after AMI. Patients having FXIIIA levels in the first quartile had a non-significant slight overrepresentation of L34-carriers both at d0 and at d4. Their frequency significantly decreased from the first to the fourth quartile, the opposite of the frequency for the VV34 genotype (p = 0.0014 and p = 0.023 at d0 and d4, respectively); (B) Distribution of patients with and without major adverse cardiovascular events (MACE+ and MACE−) stratified by FXIIIA quartiles (I-IV) assessed at baseline (d0; left panel) and four days (d4; right panel) after AMI. Patients having FXIIIA levels in the first quartile had a non-significant slight overrepresentation of MACE+ at d0, whilst at d4 they were significantly overrepresented (p = 0.0001). MACE+ frequency significantly decreased from the first to the fourth quartile, the opposite to that of MACE− (p = 0.00016 and p < 0.00001 at d0 and d4 respectively).

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  Figure 2. (A). Distribution of patients with and without major adverse cardiovascular events (MACE+ and MACE−) stratified by FXIIIA quartiles (I-IV) assessed at baseline (d0) among L34-carriers (left panel) and VV34-homozygotes (right panel). Patients having FXIIIA levels in the first quartile had a non-significant slight overrepresentation of MACE+ among L34-carriers or VV34-homozygotes. MACE+ frequency significantly decreased from the first to the fourth quartile, the opposite to that of MACE−, and this was more evident among VV34-homozygotes (p = 0.06 and p = 0.0064 among L34-carriers and VV34-homozygotes, respectively); (B) Distribution of patients with and without major adverse cardiovascular events (MACE+ and MACE−) stratified by FXIIIA quartiles (I-IV) assessed at day-four (d4) among L34-carriers (left panel) and VV34-homozygotes (right panel). Patients having FXIIIA levels in the first quartile had MACE+ overrepresented both among L34-carriers (p = 0.0036) and VV34-homozygotes (p = 0.0007). The fall in MACE+ occurrence was more evident among the VV34 genotype (p = 0.0105 and p = 0.00013 among L34-carriers and VV34-homozygotes, respectively).

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  Figure 3. Plots of Kaplan-Meier survival analysis estimated after AMI according to FXIIIA quartiles assessed at baseline (day-zero) and four days after AMI (day-four). (A) Survival curve comparison according to FXIIIA quartiles I-IV measured at day-zero. At five-year follow-up, survival rates among the different quartiles were significantly different (p = 0.000034); (B) Survival curve comparison according to FXIIIA quartiles I-IV measured at day-four. At five-year follow-up, survival rates among the different quartiles were significantly different (p = 0.000009); (C) Survival curve comparison according to FXIIIA quartile I versus quartiles II-IV computed together at day-zero. At five-year follow-up, survival in the I quartile significantly differed from that of the II-IV quartiles (p = 0.000012); (D) Survival curve comparison according to FXIIIA quartile I versus quartiles II-IV computed together at day-four. At five-year follow-up, survival in the I quartile significantly differed from that of the II-IV quartiles (p < 0.000001).

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  Figure 4. Plots of Kaplan-Meier survival analysis estimated after AMI according to FXIIIA V34L genotypes. (A) Survival curve comparison between LL34-homozygotes (LL34), VL34-heterozygotes (VL34), and VV34-homozygotes (VV34). Survival rate was not significantly different between the different genotypes; (B) Survival curve comparison between VL34-heterozygotes and LL34-homozygotes taken together (L34-carriers), and VV34-homozygotes (VV34). Survival rate was not significantly different between the two different groups of genotypes.

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  Figure 5. Plots of Kaplan-Meier survival analysis estimated after AMI according to different kinds of MACE at five-year follow-up. Cardiovascular (CV) death and heart failure (HF) combined together (red line), stroke and recurrent non-fatal ischemic events (RI) combined together (blue line). Survival significantly differed between subgroups (p = 0.0013).