Prognostic significance of N-terminal pro-atrial natriuretic factor (1-98) in acute myocardial infarction: comparison with atrial natriuretic factor (99-126) and clinical evaluation.
Why the study?
Does measurement of N-terminal pro-atrial natriuretic factor (1-98) improve prognostic assessment compared to atrial natriuretic factor (99-126) and clinical evaluation in patients with acute myocardial infarction?
Population
139 patients with acute myocardial infarction, mean age 66.9 years, 71.2% males. Excluded: cardiogenic shock…
Comparison
Measurement of plasma N-terminal pro-atrial… vs Measurement of atrial natriuretic factor and…
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
N-terminal pro-atrial natriuretic factor (1-98) may aid post-AMI mortality risk stratification; leaves open incremental value over clinical evaluation in prospective studies.
Structured PICO
Does measurement of N-terminal pro-atrial natriuretic factor (1-98) improve prognostic assessment compared to atrial natriuretic factor (99-126) and clinical evaluation in patients with acute myocardial infarction?
P
Population
139 patients with acute myocardial infarction, mean age 66.9 years, 71.2% males. Excluded: cardiogenic shock or severe heart failure (NYHA class IV).
I
Intervention
Measurement of plasma N-terminal pro-atrial natriuretic factor (1-98) concentrations in the subacute phase
C
Comparator
Measurement of atrial natriuretic factor (99-126) and clinical assessment of the degree of heart failure
O
Outcome
Cardiovascular death within 12 monthshard clinical
N-terminal pro-atrial natriuretic factor (1-98) measured in the subacute phase of AMI provides superior prognostic information for 12-month cardiovascular mortality compared to atrial natriuretic factor (99-126) and clinical evaluation.
Cite This Study
Omland et al. (1993) studied this question.