Why the study?
Does dietary restriction influence the course of infection in mice inoculated with Theiler's GDVII virus?
Does dietary restriction influence the course of infection in mice inoculated with Theiler's GDVII virus?
Dietary restriction in mice infected with Theiler's GDVII virus masks clinical signs of infection without altering overall mortality or survival time.
Reduces visible signs without survival benefit in this model; hypothesis-generating for dietary effects on viral encephalitis, needing validation before translation.
Although diets restricted either calorically or by total food intake do influence the course of infection in mice inoculated with Theiler's GDVII virus, in that frank signs of infection, i.e. paralysis, encephalitis, are frequently not evident, yet the total fatalities, the average incubation period, and the average survival time are not modified appreciably by these deficiencies.
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Davies et al. (1949) studied this question.
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