Key result
Serum DBH activity links to the ABO locus under a codominant inheritance model.
Observational (n=178)
Answers are grounded in this paper and cite their sources.
Serum dopamine-beta-hydroxylase (DBH) levels and 30 polymorphic markers were determined on 178 individuals of the HGAR 29 family, ascertained through six probands who had clinical and electrocardiographic evidence of myocardial infarction. Individuals in this pedigree with a history of heart attack had significantly lower levels of DBH, but this difference was partly confounded with age differences. Pedigree segregation analysis showed evidence of a codominant gene for DBH segregating in the family. Linkage analysis between the putative DBH locus and 30 polymorphic marker loci, assuming a codominant model, yielded a largest lod score of 0.53, with ABO at 20% recombination. Adding this to the lod scores obtained by Elston et al [1979] and Goldin et al [1982], we obtain combined lod scores of 2.49 and 2.50 at 0.0 and 10% recombination respectively.
No takes yet. Share an insight, caveat, or question.
Asamoah et al. (1987) conducted an observational in Myocardial infarction (n=178). Serum dopamine-beta-hydroxylase (DBH) activity and 30 polymorphic genetic markers vs. Individuals in the pedigree without a history of heart attack was evaluated on Genetic segregation and linkage of the putative DBH locus with 30 polymorphic marker loci (LOD score 0.53 (combined LOD 2.50 at 10% recombination)). Serum DBH activity followed a codominant gene model with a peak LOD score of 0.53 linked to ABO at 20% recombination (combined LOD 2.50 at 10% recombination).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: