Key result
DNA methylation is potentially involved in the pathogenesis of heart failure with preserved ejection fraction through pathways including myocardial fibrosis, inflammation, and metabolic defects.
Why the study?
To examine epigenetic modifications utilizing DNA methylation that are potentially involved in the pathogenesis and putative pathways of HFpEF.
Design
Review
Authors
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Epigenetic DNA methylation pathways in HFpEF remain hypothesis-generating; leaves open whether targeting them alters outcomes.
This review highlights the potential role of DNA methylation in the pathogenesis of heart failure with preserved ejection fraction (HFpEF) through various pathways including fibrosis, inflammation, and metabolic defects.
Rabkin et al. (2023) conducted a review in Heart failure with preserved ejection fraction (HFpEF). DNA methylation was evaluated. DNA methylation is potentially involved in the pathogenesis of heart failure with preserved ejection fraction through pathways including myocardial fibrosis, inflammation, and metabolic defects.
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