Why the study?
Does landiolol improve cardiac performance in male and female rats with sepsis?
RCT
Randomly allocated
No
Does landiolol improve cardiac performance in male and female rats with sepsis?
Landiolol exhibits sex-specific effects on cardiac performance in a rat model of sepsis, improving function in males but causing deleterious effects in females.
Sex-specific landiolol effects in septic rats urge clinical caution; leaves open sex-stratified human trials.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Mathieu et al. (2018) conducted an RCT in Sepsis. Landiolol vs. Sham and cecal ligation and puncture without landiolol was evaluated on In vivo cardiac function (indexed stroke volume, indexed end-diastolic volume, left ventricle ejection fraction).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: