Stereoselective Synthesis of Contiguous Cyclopropylaziridines: Enabling the Construction of Versatile Chiral Molecules Including γ‐Lactams via Ring‐Opening Reactions

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The synthesis of chiral contiguous cyclopropylaziridine was achieved through cyclopropanation of ( E )‐3‐(( S )‐1‐[( R )‐1‐phenylethyl)aziridin‐2‐yl]acrylaldehyde with bromomalonate in the presence of (2 R )‐ or (2 S )‐[diphenyl(trimethylsilyloxy) methyl]pyrrolidine as a chiral organocatalyst and 2,6‐lutidine as a base. This chiral cyclopropylaziridine was then subjected to various functional transformations, leading to the construction of a wide range of structurally important motifs.