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It has been shown recently that the expression of operons subject to catabolite repression requires 3′,5′-cyclic AMP (Perlman and Pastan, 1968; Ullmann and Monod, 1968) and a protein factor, CAP (Zubay, Schwartz, and Beckwith, 1970; Emmer, deCrombrugghe, Pastan, and Perlman, 1970). The protein factor has been partially purified from E. coli extracts with the use of mutants missing this factor. These mutants are incapable of growing on a variety of carbon sources (Schwartz and Beckwith, 1970).
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Arditti et al. (1970) studied this question.
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