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Design
Review
This review provides a foundational overview of the biochemical pathways of cGMP synthesis and degradation, emphasizing its importance as a second messenger in cardiovascular regulation.
To delineate the importance of cyclic GMP (cGMP) as a second messenger for signal transduction within the cell, catalytic and regulatory features of the proteins involved in the synthesis and degradation of cGMP, i.e., guanylate cyclases and phosphodiesterases, are described. Characteristic features of cGMP-dependent protein kinases as intracellular receptors for cGMP and the contribution of this enzyme to the physiological functions of cGMP in the cardiovascular system are discussed.
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Shoichi Imai (1995) studied this question.
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