Key result
Admission white blood cell count ≥12.00 × 10(9)/L in ACS patients was associated with higher odds of in-hospital mortality compared to <6.00 × 10(9)/L (OR 2.02; 95% CI 1.11-3.67; P=0.021).
Why the study?
Does elevated admission WBC count predict in-hospital cardiogenic shock and mortality in patients with ACS?
Observational (n=7,806)
Yes
Does elevated admission WBC count predict in-hospital cardiogenic shock and mortality in patients with ACS?
Odds Ratio: 2.02 (95% CI 1.11–3.67)
p-value: p=0.021
Elevated admission WBC count is an independent predictor of in-hospital mortality and cardiogenic shock in ACS patients.
We evaluated the relationship between admission white blood cell (WBC) count and in-hospital outcomes in acute coronary syndrome (ACS) patients from the Middle East. Data were analyzed from 7806 consecutive patients with ACS who were divided into 4 groups (G) according to their WBC count (× 10(9)/L; G1: < 6.00; G2: 6.00-9.99; G3: 10.00-11.99; G4: ≥ 12.00). After significant covariate adjustment, those in G4 were 68% more likely to have cardiogenic shock than those in G1 (95% confidence interval [CI]: 1.05-2.68; P = .030) and G2 (odds ratio [OR], 2.02; 95% CI: 1.51-2.71; P < .001). Those in G4 were 2.02 times (95% CI: 1.11-3.67; P = .021) and 65% (95% CI: 1.17-2.32; P = .004) more likely to die in hospital than those in G1 and G2, respectively. Admission WBC count is an independent risk factor for in-hospital cardiogenic shock and mortality, in Middle Eastern patients with ACS. Novel therapeutic agents targeting WBCs in patients with ACS may improve outcomes.
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Sulaiman et al. (2011) conducted an observational in Acute Coronary Syndrome (n=7,806). Admission white blood cell count ≥ 12.00 × 10(9)/L vs. Admission white blood cell count < 6.00 × 10(9)/L was evaluated on In-hospital mortality (OR 2.02, 95% CI 1.11-3.67, p=0.021). Admission white blood cell count ≥12.00 × 10(9)/L in ACS patients was associated with higher odds of in-hospital mortality compared to <6.00 × 10(9)/L (OR 2.02; 95% CI 1.11-3.67; P=0.021).
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