Key result
Vascular endothelial function, assessed by reactive hyperemia index, was not significantly different between patients with OHSS and healthy controls (mean 1.8 vs 1.7).
Why the study?
The study tested whether vascular endothelial function, assessed by reactive hyperemia index, and biochemical factors including VEGF, TNFα, CRP, inhibin A, and inhibin B, are involved in the pathogenesis of OHSS.
Is vascular endothelial function, as measured by reactive hyperemia index, impaired in patients with ovarian hyperstimulation syndrome compared to healthy controls?
Case-Control (n=21)
Is vascular endothelial function, as measured by reactive hyperemia index, impaired in patients with ovarian hyperstimulation syndrome compared to healthy controls?
This pilot study found no direct evidence of peripheral vascular endothelial dysfunction, as measured by reactive hyperemia index, in patients with ovarian hyperstimulation syndrome.
No difference in endothelial function in OHSS; hypothesis-generating and requires prospective validation before clinical relevance.
OBJECTIVE: The current study tested the hypothesis that vascular endothelial function, as reflected by the reactive hyperemia index (RHI), and biochemical factors, including VEGF, TNFα, CRP, inhibin A, and inhibin B, were involved in the pathogenesis of ovarian hyperstimulation syndrome (OHSS). MATERIALS AND METHODS: This study was conducted between June 2010 and June 2012, enrolling 15 patients with OHSS and 6 healthy control subjects <45 years of age. Detailed clinical parameters were reviewed, including serum VEGF, TNFα, CRP, inhibin A, inhibin B, and hematocrit. RHI assessed by novel automatic peripheral arterial tonography was used to evaluate the vascular endothelial function. RESULTS: Twenty-one subjects were evaluated. There was no significant difference between patients with OHSS and control subjects with respect to VEGF, TNFα, CRP, inhibin A and inhibin B. The RHI was not significantly different between patients with OHSS and control subjects (mean, 1.8 ± 0.4 vs. 1.7 ± 0.2). The hematocrit was significantly different between patients with OHSS and control subjects. CONCLUSIONS: Our preliminary data did not reveal direct evidence of vascular endothelial dysfunction in patients with OHSS. To identify whether RHI could reflect vascular endothelial dysfunction in patients with OHSS, more cases with different severities of OHSS should be recruited in the future study.
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Chin et al. (2019) conducted a case-control in Ovarian hyperstimulation syndrome (OHSS) (n=21). Ovarian hyperstimulation syndrome (OHSS) vs. Healthy control subjects was evaluated on Reactive hyperemia index (RHI). Vascular endothelial function, assessed by reactive hyperemia index, was not significantly different between patients with OHSS and healthy controls (mean 1.8 vs 1.7).
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