Chlorogenic acid (400 mg) acutely lowered mean systolic blood pressure by 2.41 mmHg (95% CI -4.78 to -0.03; P=0.05) and diastolic blood pressure by 1.53 mmHg compared to placebo in healthy adults.
RCT (n=23)
Double-blind
Crossover
Mean Difference: -2.41 (95% CI -4.78–-0.03)
p-value: p=0.05
There is mounting evidence that specific dietary polyphenols can enhance vascular health by augmenting nitric oxide. Our aim was to investigate the acute effects of chlorogenic acid, an important dietary phenolic acid present in coffee (400 mg, equivalent to 2 cups of coffee), on nitric oxide status, endothelial function, and blood pressure. Healthy men and women (n = 23) were recruited to a randomized, double-blind, placebo-controlled, crossover trial. Chlorogenic acid resulted in significantly higher plasma concentrations of chlorogenic acid (P 0.10) and the measure of endothelial function (P = 0.60) were not significantly influenced. Chlorogenic acid can lower blood pressure acutely, an effect that, if sustained, would benefit cardiovascular health.
Mubarak et al. (Mon,) conducted a rct in Healthy volunteers (n=23). Chlorogenic acid vs. Placebo was evaluated on Mean post-treatment systolic blood pressure (MD -2.41 mmHg, 95% CI -4.78 to -0.03, p=0.05). Chlorogenic acid (400 mg) acutely lowered mean systolic blood pressure by 2.41 mmHg (95% CI -4.78 to -0.03; P=0.05) and diastolic blood pressure by 1.53 mmHg compared to placebo in healthy adults.