Key result
Chlorogenic acid (400 mg) acutely lowered mean systolic blood pressure by 2.41 mmHg (95% CI -4.78 to -0.03; P=0.05) and diastolic blood pressure by 1.53 mmHg compared to placebo in healthy adults.
Why the study?
Does chlorogenic acid 400 mg improve nitric oxide status, endothelial function, and blood pressure in healthy volunteers?
RCT (n=23)
Double-blind
Crossover
Does chlorogenic acid 400 mg improve nitric oxide status, endothelial function, and blood pressure in healthy volunteers?
Mean Difference: -2.41 (95% CI -4.78–-0.03)
p-value: p=0.05
Chlorogenic acid acutely lowers systolic and diastolic blood pressure in healthy volunteers, though it does not significantly influence nitric oxide status or endothelial function.
Acute chlorogenic acid modestly lowers BP in healthy adults; extends evidence for effects independent of nitric oxide or endothelial function.
There is mounting evidence that specific dietary polyphenols can enhance vascular health by augmenting nitric oxide. Our aim was to investigate the acute effects of chlorogenic acid, an important dietary phenolic acid present in coffee (400 mg, equivalent to 2 cups of coffee), on nitric oxide status, endothelial function, and blood pressure. Healthy men and women (n = 23) were recruited to a randomized, double-blind, placebo-controlled, crossover trial. Chlorogenic acid resulted in significantly higher plasma concentrations of chlorogenic acid (P < 0.001). Relative to control, the mean post-treatment systolic blood pressure (-2.41 mmHg, 95% CI: -0.03, -4.78; P = 0.05) and diastolic blood pressure (-1.53 mmHg, 95% CI: -0.05, -3.01; P = 0.04) were significantly lower with chlorogenic acid. Markers of nitric oxide status (P > 0.10) and the measure of endothelial function (P = 0.60) were not significantly influenced. Chlorogenic acid can lower blood pressure acutely, an effect that, if sustained, would benefit cardiovascular health.
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Mubarak et al. (2012) conducted an RCT in Healthy volunteers (n=23). Chlorogenic acid vs. Placebo was evaluated on Mean post-treatment systolic blood pressure (MD -2.41 mmHg, 95% CI -4.78 to -0.03, p=0.05). Chlorogenic acid (400 mg) acutely lowered mean systolic blood pressure by 2.41 mmHg (95% CI -4.78 to -0.03; P=0.05) and diastolic blood pressure by 1.53 mmHg compared to placebo in healthy adults.
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