PASCHKIS and coworkers (1944) reported the excretion of androgens in the bile of dogs after the intravenous administration of testosterone, androsterone, and methyltestosterone. We have studied the biliary excretion of androgens after testosterone administration in three humans. Longwell and McKee (1942) and Cantarow et al. (1942, 1942a, 1943, 1943a, 1943b) have found relatively large amounts of estrogen in the bile of bile-fistula dogs injected subcutaneously with various amounts of estrone and estradiol. The latest report from this group (Pearlman, 1945) indicates a lower recovery of estrogen from the dog’s bile than was first reported, but the amount in the bile was still quite significant, 10.4 per cent of the estrogenic activity and 39.3 per cent of the estrogenic material being recovered. Stimmel (1951) has reported recovery of 3 per cent and 7.7 per cent of administered estroil in human bile, and failure to recover any administered estrone or estradiol. We have studied biliary estrogens in one of the three patients.
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Rubin et al. (1952) studied this question.