Aureoquinone, a New Protease Inhibitor from Aureobasidium sp.

Searchingfor new bioactive metabolites of basidiomycetes we isolated recently the new metabolite aureoquinone (1) (Fig. 1) as an inhibitor of several proteases from surface cultures of Aureobasidium sp.grown on a synthetic medium.The strain was originally isolated from a fruiting body of Crepidotus sp.collected in the Picea-fovQSt near Radison (Quebec, Canada).Aureobasidium sp.forms smooth colonies with a dark