BIPA: a database for protein–nucleic acid interaction in 3D structures

UNLABELLED: BIPA is a database for protein-nucleic acid interactions in 3D structures. The database provides various physicochemical features of protein-nucleic acid interface such as size, shape, residue propensity, secondary structure composition and intermolecular interactions. The database also contains multiple structural alignments of nucleic acid-binding protein families with annotations of local environments in order to allow definition of features that influence acceptability of mutations at a particular position in a protein family. A web interface has been designed to present the results of these analyses and facilitate navigation of protein-nucleic acid interfaces. AVAILABILITY: http://www-cryst.bioc.cam.ac.uk/bipa SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.