Key result
Fetuses conceived by IVF with fresh or frozen embryo transfer showed cardiac remodeling, including a larger right atria-to-heart ratio (18.1% and 18.0% vs 17.3%; P<0.001) compared to controls.
Why the study?
Fetuses conceived by ARTs show cardiac remodeling and suboptimal function, mostly studied after fresh embryo transfer (ET), but no previous studies have compared fetal cardiac morphology and function between fresh ET and frozen embryo transfer (FET).
Does IVF with fresh or frozen embryo transfer cause fetal cardiac remodeling compared to spontaneous conception?
Cohort (n=300)
No
Does IVF with fresh or frozen embryo transfer cause fetal cardiac remodeling compared to spontaneous conception?
Fetuses conceived by IVF (both fresh and frozen embryo transfer) exhibit subclinical cardiac remodeling and suboptimal function compared to spontaneously conceived fetuses, with changes being more pronounced following fresh embryo transfer.
Signs of cardiac remodeling after both ET types support fetal monitoring; leaves open whether fresh ET poses higher risk than FET.
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Boutet et al. (2021) conducted a cohort in Singleton pregnancies conceived by ARTs (n=300). IVF with fresh or frozen embryo transfer vs. Spontaneously conceived pregnancies was evaluated on Right atria-to-heart ratio (p=<0.001). Fetuses conceived by IVF with fresh or frozen embryo transfer showed cardiac remodeling, including a larger right atria-to-heart ratio (18.1% and 18.0% vs 17.3%; P<0.001) compared to controls.
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