What question did this study set out to answer?

To determine whether parental origin alters the phenotypic expression of variegation in female mice carrying the T(1; X)Ct translocation.

February 1, 1970Genetics ResearchOpen Access

Parental influence onX-autosome translocation-induced variegation in the mouse

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To determine whether parental origin alters the phenotypic expression of variegation in female mice carrying the T(1; X)Ct translocation.
Assessed levels of c-variegation in female mice heterozygous for the T(1; X)Ct X-autosome translocation based on maternal versus paternal inheritance of the rearranged chromosome.
Evaluated parental inheritance patterns to distinguish between maternal effects, parental-source modifications, and skewed X-inactivation.
Female mice show reduced levels of c-variegation when the rearranged X chromosome is inherited from the father compared to when it is inherited from the mother.
The disparity in variegation levels is not attributable to a maternal effect, indicating either an active parental-source modification or biased inactivation between maternal and paternal X chromosomes.

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Implication

Genetic analysis reveals reduced c-variegation in female mice inheriting rearranged X chromosomes from fathers, indicating a parental-source effect or skewed X-inactivation.

Cite This Study

Cattanach et al. (1970) studied this question.

synapsesocial.com/papers/6a74a6d8f5fc394144032eb9 https://doi.org/10.1017/s0016672300001361

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Implication

Genetic analysis reveals reduced c-variegation in female mice inheriting rearranged X chromosomes from fathers, indicating a parental-source effect or skewed X-inactivation.

Parental influence onX-autosome translocation-induced variegation in the mouse

Key Points

Discussion

Implication

Cite This Study

Parental influence onX-autosome translocation-induced variegation in the mouse

Key Points

Discussion

Implication

Cite This Study

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