Key result
Maternal diabetes exposure in utero was associated with a significant increase in VCAM in infant cord serum compared to normal glycemia (p=0.046), while ICAM and E-selectin were not different.
Why the study?
Soluble adhesion molecules are associated with cardiovascular disease and elevated in diabetes, but the impact of in utero diabetes exposure on circulating adhesion molecules in cord serum and endothelial release is unclear.
Does maternal diabetes exposure in utero increase the abundance of soluble adhesion molecules in infant cord serum?
Observational (n=77)
Does maternal diabetes exposure in utero increase the abundance of soluble adhesion molecules in infant cord serum?
Maternal diabetes exposure increases VCAM in infant cord serum, which may reflect early alterations in vascular function predicting future cardiovascular disease.
Answers are grounded in this paper and cite their sources.
In utero DM exposure may alter fetal endothelial adhesion profiles; leaves open whether this programs later offspring cardiovascular risk.
Soluble adhesion molecules are associated with cardiovascular disease and increased in individuals with diabetes. The current study assesses the impact of diabetes exposure in utero on the abundance of circulating adhesion molecules in cord serum as well as soluble adhesion molecules released from human umbilical vein endothelial cells (HUVEC) upon exposure to high levels of glucose. Women with and without diabetes (DM; gestational or type 2) were recruited at delivery. DM was diagnosed based on the criteria by the American Diabetes Association. Primary cultures of HUVEC were established in M199 medium with growth supplements. For the high glucose treatment, medium was adjusted to a final glucose concentration of 25mM with media collected 48 hours post treatment. The soluble adhesion molecules intracellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) and E-selectin were measured by ELISA in the cord blood serum and the conditioned HUVEC media. Serum adhesion molecules were measured in 42 infants born to mothers with normal glycemia and 35 infants of mothers with DM. The mothers with DM were older with higher BMI (p=0.027 and 0.008, respectively). In a fully adjusted model, VCAM was significantly increased in the cord serum of infants born to mothers with diabetes (p=0.046), but ICAM and E-selectin were not different. ICAM was significantly correlated with E-selectin (r2=0.25, p<0.001), but not VCAM. ICAM was also significantly correlated with maternal HbA1c (r2=0.16, p=0.004) and cord serum non-esterified fatty acids (r2=0.08, p=0.013). From the HUVEC, the abundance of adhesion molecules was not different based on DM or high glucose exposure; however, VCAM abundance in the HUVEC supernatant was significantly correlated with ICAM (r2=0.27, p=0.010) and cord serum insulin (r2=0.19, p=0.042). Alterations in soluble adhesion molecule abundance in infants exposed to the diabetic milieu of pregnancy may reflect early alterations in vascular function predicting future cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
LANDRETH et al. (2021) conducted an observational in Maternal diabetes exposure in utero (n=77). Maternal diabetes exposure in utero vs. Normal glycemia was evaluated on Abundance of circulating adhesion molecules (VCAM, ICAM, E-selectin) in cord serum (p=0.046). Maternal diabetes exposure in utero was associated with a significant increase in VCAM in infant cord serum compared to normal glycemia (p=0.046), while ICAM and E-selectin were not different.
Synapse has enriched 5 related papers. Consider them for comparative context: