This study reports a high incidence of dysphoric reactions to Δ9-tetrahydrocannabinol (THC) administered under double-blind conditions to a well-defined homogeneous population of hospitalized patients with unipolar depressive illness. Personality characteristics that might predispose patients to dysphoric reactions are examined and the implications of the effect of THC on the mood of depressed patients are discussed.
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Ablon et al. (1974) studied this question.
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