Key result
Transventricular placement of a 2-Fr ultraminiature pressure-tip catheter was accurate and comparable to a 5-Fr catheter for measuring left ventricular pressure in piglets.
Why the study?
Does a 2-Fr ultraminiature pressure-tip catheter provide accurate left ventricular pressure measurements compared to a 5-Fr catheter in a piglet model?
Does a 2-Fr ultraminiature pressure-tip catheter provide accurate left ventricular pressure measurements compared to a 5-Fr catheter in a piglet model?
Effect estimate: Reliability coefficients 0.87-0.99
Transventricular placement of a 2-Fr pressure-tip catheter is feasible and provides accurate left ventricular pressure measurements comparable to a 5-Fr catheter in a piglet model, supporting its potential use in pediatric congenital heart surgery.
May support smaller-catheter use in pediatric animal models; leaves open translation to congenital heart surgery.
Pressure-tip catheters (PTCs) are used to evaluate ventricular mechanics during surgical repair of congenital heart disease in children. Studies in infants require miniaturized sensors. We compared the safety and accuracy of a 2-Fr ultraminiature PTC with a 5-Fr PTC. In 10 piglets (weight 19-22 kg), a 5-Fr PTC was inserted through a 3-mm apical puncture with a #11 blade. A 20-gauge angiocatheter was inserted using a separate site. A 2-Fr PTC was threaded through the angiocatheter lumen. The angiocatheter was withdrawn, leaving the 2-Fr PTC within the left ventricle (LV). Left ventricular pressure (LVP) changes were measured during three inferior vena caval occlusions. Reliability coefficients demonstrated correlation between the 2-Fr PTC and 5-Fr PTC for LV end-diastolic pressure (0.90-0.95), peak LVP (0.92-0.99), and the maximal (0.87-0.93) and minimal (0.89-0.94) first derivatives of LVP. Bland-Altman analysis demonstrated agreement for all variables. Blood loss was trivial with pressure manipulation and catheter placement and removal. Pressure measurements using the 2-Fr PTC were accurate and comparable with those from the 5-Fr PTC. Transventricular placement of a 2-Fr PTC is feasible and should allow evaluation of ventricular mechanics during surgical repair of congenital heart disease.
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Gray et al. (2010) studied this question. 2-Fr ultraminiature pressure-tip catheter vs. 5-Fr pressure-tip catheter was evaluated on Left ventricular pressure changes (LV end-diastolic pressure, peak LVP, maximal and minimal first derivatives of LVP) (Reliability coefficients 0.87-0.99). Transventricular placement of a 2-Fr ultraminiature pressure-tip catheter was accurate and comparable to a 5-Fr catheter for measuring left ventricular pressure in piglets.
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