Why the study?
Does lysophosphatidylcholine decrease the single channel conductance of the inward rectifier K channel in isolated guinea pig ventricular myocytes?
Does lysophosphatidylcholine decrease the single channel conductance of the inward rectifier K channel in isolated guinea pig ventricular myocytes?
Lysophosphatidylcholine decreases the single channel conductance of the inward rectifier K channel, providing a molecular mechanism for LPC-induced depolarization of cardiac tissues during ischemia.
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Hypothesis-generating for LPC-mediated IK1 inhibition in ischemia; requires confirmation in mammalian models before clinical relevance.
Effect of lysophosphatidylcholine (LPC) on the inward rectifier K channel of the isolated guinea pig ventricular cell was studied using patch clamp technique. In that LPC (100 microM) decreased the magnitude of the single channel conductance from 48 +/- 5 pS (mean and S.D., n = 5) to 12 +/- 9 pS (n = 8), this event may be the prime factor related to the alleged LPC-induced depolarization of cardiac tissues.
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Kiyosue et al. (1984) studied this question.
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