Answers are grounded in this paper and cite their sources.
Dimethyl fumarate (DMF) is an oral medication for multiple sclerosis (MS) that is prescribed in part for its favorable safety profile. There have been 5 reported cases of progressive multifocal leukoencephalopathy (PML) with the use of fumaric acid esters in patients with psoriasis.1 Some have been on concomitant or prior immunosuppression and most had absolute lymphocyte counts (ALC) below 500. To date, 4 cases of PML (one published) have been reported in patients with MS on DMF (personal communication, Biogen, 2016).2 Herein, we report the details of one of these 4 cases: nonfatal PML in a patient with MS on DMF.
No takes yet. Share an insight, caveat, or question.
Baharnoori et al. (2016) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: