during pregnancy, and histological changes in the decidua and fetal organs resemble those present after naturally acquired maternal disease.3Until more information has been collected, pregnancy must remain a contraindication to rubella vaccination.Nevertheless, inadvertent vaccination during pregnancy will undoubtedly still occur, and unfortunately many who have not been screened for rubella antibodies will be advised to have their pregnancies terminated.We think that this fetal wastage could be considerably reduced, since our results show that if patients not screened for rubella antibodies before vaccination have virological assessment within eight weeks of receiving RA 27/3 vaccine, it is possible to determine whether their antibody results from recent vaccination or from past infection.Results after vaccination with Cendehill vaccine are somewhat less reliable, however, unless the vaccine has induced a reasonably high HAI antibody response (for example, > 1/32 in our study).
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Serebro et al. (1977) studied this question.