Key result
Exposure to cadmium oxide nanoparticles and ultrafine carbon black induced protein citrullination in cultured human lung epithelial cells, primarily targeting type I and II cytokeratins.
Population
Human A549 lung epithelial cells
Design
Preclinical
Authors
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May link nanoparticle exposure to lung citrullination; leaves open role in COPD pathogenesis.
Cadmium oxide nanoparticle exposure facilitates post-translational citrullination of cytokeratins in lung epithelial cells, suggesting a potential mechanism for autoimmunity in COPD.
Hutchinson et al. (2018) studied Chronic obstructive pulmonary disease. Cadmium (CdCl2 and CdO) and ultrafine carbon black was evaluated on Intracellular protein citrullination. Exposure to cadmium oxide nanoparticles and ultrafine carbon black induced protein citrullination in cultured human lung epithelial cells, primarily targeting type I and II cytokeratins.
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