Why the study?
What is the optimal revascularization strategy (PCI vs CABG) in diabetic patients with coronary artery disease?
What is the optimal revascularization strategy (PCI vs CABG) in diabetic patients with coronary artery disease?
In diabetic patients with coronary artery disease, the choice between PCI and CABG must be tailored to individual clinical and anatomical factors, as diabetes magnifies cardiovascular risk and worsens outcomes compared to non-diabetics.
Diabetes mellitus is becoming increasingly prevalent and magnifies the risk of cardiovascular complications. Endothelial dysfunction caused by oxidative stress is a hallmark of diabetes and is responsible for the ubiquitous manifestations of vascular disease in diabetics. Compared with non-diabetic patients, coronary artery disease is more severe and the clinical outcome impaired in diabetic patients undergoing revascularisation. Despite these limitations the benefit of revascularisation therapy is particularly pronounced in diabetics. The optimal revascularisation strategy (coronary artery bypass graft surgery versus percutaneous coronary intervention) in diabetic patients with coronary artery disease depends on clinical and anatomical considerations.
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Cook et al. (2009) conducted a review in Coronary artery disease in patients with diabetes mellitus. Percutaneous coronary intervention (PCI) vs. Coronary artery bypass grafting (CABG) was evaluated.
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