The avidity of antibodies produced by single cells has been studied using inhibition of hemolytic plaque formation by free antigen as a test system. The effect of a paralyzing injection of antigen into mice immunized with heterologous albumins was studied. After a lag period of approximately two days the number of plaque‐forming cells (PFC) decreased in the paralyzed mice. The PFC that remained in the paralyzed animals released antibodies with a low avidity for the antigen as compared to control PFC. The impact of an injection of antibody into immune mice was then studied. A reduction in the number of PFC was found in the antiserum suppressed animals. The remaining PFC released antibody of a relatively high avidity for the antigen. The data support the concept of a similar binding constant for the cell‐associated antibody‐like receptor operating in induction of immunity and paralysis and the antibody released from the cell after stimulation.
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Andersson et al. (1971) studied this question.
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