Key result
The number of wild poliovirus type 1 cases in Pakistan surged to 72 during January–September 2019, compared with 4 cases during the same period in 2018, indicating widespread transmission.
Why the study?
During January 2018-September 2019, wild poliovirus type 1 (WPV1) cases in Pakistan increased compared with the previous 4 years, prompting an update on eradication activities, progress, and challenges.
Observational (n=23,076)
The resurgence of wild poliovirus type 1 in Pakistan during 2018-2019 highlights critical operational and community challenges that must be addressed to achieve global polio eradication.
Answers are grounded in this paper and cite their sources.
Pakistan's rising WPV1 cases signal need for enhanced eradication measures; leaves open questions on barriers to polio elimination.
Afghanistan and Pakistan are the only countries that continue to confirm ongoing wild poliovirus type 1 (WPV1) transmission (1). During January 2018-September 2019 the number of WPV1 cases in Pakistan increased, compared with the number during the previous 4 years. This report updates previous reports on Pakistan's polio eradication activities, progress, and challenges (2,3). In 2018, Pakistan reported 12 WPV1 cases, a 50% increase from eight cases in 2017, and a 31% increase in the proportion of WPV1-positive sites under environmental surveillance (i.e., sampling of sewage to detect poliovirus). As of November 7, 2019, 80 WPV1 cases had been reported, compared with eight cases by the same time in 2018. An intensive schedule of supplementary immunization activities (SIAs)* implemented by community health workers in the core reservoirs (i.e., Karachi, Peshawar, and Quetta) where WPV1 circulation has never been interrupted, and by mobile teams, has failed to interrupt WPV1 transmission in core reservoirs and prevent WPV1 resurgence in nonreservoir areas. Sewage samples have indicated wide WPV1 transmission in nonreservoir areas in other districts and provinces. Vaccine refusals, chronically missed children, community campaign fatigue, and poor vaccination management and implementation have exacerbated the situation. To overcome challenges to vaccinating children who are chronically missed in SIAs and to attain country and global polio eradication goals, substantial changes are needed in Pakistan's polio eradication program, including continuing cross-border coordination with Afghanistan, gaining community trust, conducting high-quality vaccination campaigns, improving oversight of field activities, and improving managerial processes to unify eradication efforts.
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Hsu et al. (2019) conducted an observational in Poliomyelitis (n=23,076). Wild poliovirus type 1 (WPV1) transmission vs. Previous time periods (2017 and early 2018) was evaluated on Number of reported WPV1 cases. The number of wild poliovirus type 1 cases in Pakistan surged to 72 during January–September 2019, compared with 4 cases during the same period in 2018, indicating widespread transmission.
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