Answers are grounded in this paper and cite their sources.
Potent anticonvulsant activity has been demonstrated for a large number of 1-(naphthylalkyl)-1H-imidazoles containing a variety of functional groups in the alkylene bridge. The presence of a small oxygen function in the bridge, in general, confers a high therapeutic index between anticonvulsant and depressant activity. Clinical expectations are discussed for 1-(2-naphthoylmethyl)imidazole hydrochloride (5), which is undergoing development for testing in humans.
No takes yet. Share an insight, caveat, or question.
Walker et al. (1981) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: