Long-term nonsteroidal anti-inflammatory drug use is associated with rotator cuff tears in adult patients

This is the authors' abstract. We don't add key points for this paper.

Background: To determine if long-term nonsteroidal anti-inflammatory drug (NSAID) is associated with rotator cuff tears (RCTs) in an adult population. Methods: A retrospective study using a national database was performed. All patients with a diagnosis of long-term NSAID use with active records for at least 1 year or 2 years were identified. These patients were matched 1:1 to controls without NSAID use based on age, gender, and Charlson comorbidity index. Rates of new rotator cuff tendon tears were compared. Subgroup analyses in the following age ranges for each sex were done: 35-45, 46-55, 56-65, and 66-75. Conclusion: Long-term NSAID use is associated with an increased incidence of rotator cuff tendon tears at the 1- and 2-year follow-up periods in adult patients, particularly those in the 46-55 age range.