An integrated approach to the treatment of diffuse peritonitis in children

The purpose of the study . Improving the treatment of advanced peritonitis with using in therapy antihypoxant Reamberin and hepatoprotector Remaxol, nutritional support, sanitation laparoscopic abdominal cavity. Materials and methods. A total of 327 children aged 1 to 15 years with generalized purulent peritonitis treated at the children's surgical departments of Samara from 2001 to 2018. A study group comprised 241 patients who used the optimized pathogenetic therapy. In the study group was allocated two groups: 69 patients in the pathogenetic therapy that used antihypoxant Reamberin, and 110 children in the treatment of which Reamberin and hepatoprotector Remaxol. All the children of the main group received nutritional support (trophic feedings), used in the surgical treatment of abdominal laparoscopic sanitation. Comprehensive survey includes the study of the dynamics of the level of white blood cells, leukocyte index, total albumin concentration. Results. Comparison of the studied parameters in the study and control groups, showed a more rapid decrease in the symptoms and signs of intoxication (leukocytosis, LII), relief of enteric disease, recovery of protein-synthetic function of the liver, a decrease of cytolytic and mesenchymal-inflammatory syndrome in the study group, especially in the subgroup in which therapy was included Remaxol. Conclusions . Optimization of treatment involving the application of the combined drugs – antihypoxant Reamberin, hepatoprotector Remaxol, nutritional support and implementation of laparoscopic abdominal sanitation led to improved results of therapy common purulent peritonitis in children.